2025 Sunday Night Baseball Lines - Cardinals at Red Sox

2025 Sunday Night Baseball Betting

Sunday Night Baseball is ESPN’s marquee weekly Major League Baseball (MLB) broadcast, airing live on Sunday nights throughout the season. Featuring high-profile matchups, the telecast includes in-depth analysis, player interviews, and expert commentary from ESPN’s top baseball analysts. As the only nationally televised MLB game on Sunday nights, it often showcases the league’s biggest teams and stars, making it a must-watch event for baseball fans.

The St. Louis Cardinals visit the Boston Red Sox in Sunday Night baseball betting on ESPN on Sunday, April 6. It has been a so-so start for St. Louis early in the season, while the Red Sox are off to a poor start. The Cardinals are playing in what is expected to be a mediocre National League Central so a start of around .500 is just fine. The same cannot be said about the Red Sox, as Boston plays in a very tough American League East and a slow start could be a disaster. The Cardinals should be sending Miles Mikolas to the mound on Sunday night, while the Red Sox seem likely to go with Sean Newcomb. Despite the slow start, the Red Sox will likely be favored in Sunday Night Baseball betting odds.

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Sunday, April 6

St. Louis Cardinals at Boston Red Sox, 7:10 PM Eastern (ESPN)

The Cardinals will be playing their first road series of the season, as they visit the Red Sox. St. Louis was home for their first two series against the Angels and Twins. St. Louis was not that bad on the road a year ago, as they went 39-42 and anytime a team is close to .500 on the road they are doing well. The Cardinals last season didn’t really take care of business at home, as they were just barely above .500 which is why they missed the playoffs. The Red Sox will be playing their first home series of the season, as Boston started on the road and struggled against Texas and Baltimore. The Red Sox were a flop last season at Fenway Park, as they actually had a losing record of 38-43 at home last season.

The Cardinals are expected to go with Miles Mikolas in this game, while the Red Sox throw Sean Newcomb. Mikolas went 5.1 innings in his first start of the season against the Angels and allowed two runs and two hits to go along with two walks. He picked up a no-decision in a game the Cardinals lost 5-4 in 10 innings. He was just 10-11 last season for the Cardinals with an ERA of 5.35.

Newcomb went just four innings in his first start of the season and gave up four runs and eight hits to Baltimore in an 8-5 loss. Newcomb only pitched in seven games for the A’s last season and wasn’t that effective with an ERA over six. Newcomb did pitch well in Spring Training for the Red Sox and won the fifth starter job.

The Cardinals have held their own recently on the road in Boston, as they have split the last 10 meetings with five of those games going over, three going under, with two pushes. The last time the Cardinals and Red Sox met for a series at Fenway was in 2023 and St. Louis won all three games.

2025 Sunday Night Baseball Betting Schedule

ESPN will be showing 25 games for their 2025 Sunday Night Baseball schedule. ESPN released the early part of their schedule with 14 games announced from March 30 to August 17. The other 11 Sunday Night Baseball games will be announced at a later date.

*Little League Classic

ESPN will be showing a total of 25 Sunday Night Baseball games in 2025. Their broadcasts being with a game in late March and continue throughout the regular season, concluding with a game in late September. Many of the game’s top stars will be featured on Sunday Night Baseball including Shohei Ohtani, Aaron Judge, Juan Soto, Mookie Betts, Ronald Acuña Jr., Bryce Harper, among others. The Los Angeles Dodgers and New York Mets will have the most appearances with four each, while the Philadelphia Phillies and San Diego Padres will have three appearances each. Some of the highlights of the 2025 Sunday Night Baseball schedule are a World Series rematch, as the Yankees visit the Dodgers on June 1, the Subway Series with the Mets visiting the Yankees during MLB Rivalry Week on May 18, a National League Championship Series rematch with the Los Angeles Dodgers visiting the New York Mets on May 25, a special Fourth of July weekend doubleheader on July 6 that includes the Rangers at the Padres and the 2025 MLB Little League Classic with the Seattle Mariners taking on the New York Mets on August 17.

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