49ers at Dolphins NFL Week 16 Betting Lines

San Francisco 49ers NFL Week 16 Betting Lines

Fresh off a dominant performance against the Chicago Bears, the San Francisco 49ers faltered in a quick turnaround, suffering a 12-6 loss and non-NFL odds cover against the division rival Los Angeles Rams. The defeat effectively extinguished the Niners' slim playoff hopes, leaving them with less than a 1 percent chance of making the postseason. After three consecutive playoff appearances, the reigning NFC champions are on the brink of elimination, needing to win out and receive significant help to have any shot. The season has been an uphill battle since Week 1. From Christian McCaffrey's unexpected absence in the opener against the Jets, to Brandon Aiyuk's contract disputes, and numerous season-ending injuries incurred on both sides of the ball, the odds were stacked against them from the start. Now, speculation swirls around Kyle Shanahan's future with the franchise amid concerns the team’s Super Bowl window has closed. As the 49ers face the reality of a lost season, questions arise about their motivation moving forward, knowing every win impacts their draft positioning. Pride may still fuel their effort, but it’s uncertain how focused the team will be as they prepare to face the Miami Dolphins in Week 16 betting action.

Back in the loss column for the eighth time, San Francisco’s odds of winning Super Bowl LIX swelled to 1000-1 from 110-1, while its odds of taking down successive NFC titles also jumped to 1000-1 from 50-1. The 49ers’ odds of winning a third straight NFC West title have been taken off the board with it mathematically impossible. Same goes for their adjusted in-season win total which clocked in at a season-low 7.5 with exorbitant juice affixed to the over last we checked. Initially -450 favorites to punch a ticket to the playoffs, San Fran is now a +10000 underdog to do so, with the “No” not a betting option any longer after demanding a $2000 investment to make $100 last week.

NFL Week 16 Betting Lines

San Francisco 49ers +1

Miami Dolphins -1

Over/Under: 45.5

Money Line: 49ers -103, Dolphins -116

San Francisco 49ers Week 16 Matchup

On Sunday, December 22, 2024, the San Francisco 49ers will take on the Miami Dolphins from Hard Rock Stadium in Miami Gardens, FL. Kickoff time is set for 4:25 p.m. ET with television coverage on CBS. The lookahead NFL Week 16 betting odds hit the board with the 49ers installed 2-point underdogs and the total lined 49.5. Though the Niners have taken in 70+ percent of the bets, it’s Miami that’s been hammered with 60+ percent of the money. Because of it, NFL crypto bettors find San Francisco installed road dogs for the third straight time venturing away from the comforts of Silicon Valley—albeit short 1-point pups. Regardless, the 49ers will be out to snap a two-game road losing streak after dropping back-to-back games to the Packers and Bills which moved the team to 2-4 straight up (SU) and bankroll killing 1-5 against the spread (ATS) as visitors to date. The Over/Under split in those matchups with an average of 47.8 points scored. Even so, total bettors appear enamored with the under evidenced by 70+ percent of the tickets and handle expecting points to be tough to come by ultimately forcing a huge market correction down to 44.5 with heavier juice still affixed to the impost’s low side. Injuries are playing a role so check reports to see which of the walking wounded actually gives it a go.

San Francisco 49ers Week 15 Recap

The San Francisco 49ers suffered a crushing 12-6 loss to the Los Angeles Rams, further dimming their playoff hopes. The Niners led 6-3 entering the fourth quarter but faltered late, marking their fourth NFL odds loss this season after holding a fourth-quarter lead against a division rival—a dubious feat not seen since New England in 2000. Brock Purdy struggled, completing just 14 of 31 passes for 142 yards with a costly fourth-quarter interception in the end zone by Darious Williams. The 49ers' offense failed to score a touchdown for the first time since 2019, stymied by poor weather in the first half and disjointed play throughout. The team managed just nine first downs and 197 total yards in a game dominated by both punters (11 combined). The Niners’ defense held strong early, forcing four straight punts from the Rams, and Fred Warner tallied key stops, but lapses late allowed a 51-yard Stafford-to-Puka Nacua pass that led to the Rams' go-ahead field goal. Injuries compounded issues: LB Dre Greenlaw returned but played sparingly, and S Ji’Ayir Brown exited with a groin injury. The loss solidifies a frustrating narrative for the defending NFC champions—opportunities squandered in crucial moments.

2024 San Francisco 49ers Schedule, Results & Record

Founded in 1946 as members of the All-American Football Conference (AAFC), the San Francisco 49ers have established a rich history that places them among the NFL’s legacy franchises. They won the final AAFC championship in 1949 before the league merged with the NFL. However, from 1950 through 1969, the 49ers made the playoffs only once.

The 1970s saw a resurgence, with the 49ers winning the NFC West three consecutive seasons from 1970 to 1972 and reaching the NFC Championship Game twice. Quarterback John Brodie and wide receiver Gene Washington were standout stars during this period. The 49ers' first dynasty began in 1981 under the leadership of Bill Walsh, who guided the team to three Super Bowl championships between 1981 and 1988. After Walsh retired, the team, coached by George Seifert, won another Super Bowl the following year and secured the franchise's final Super Bowl in 1994. From 1983 to 1998, San Francisco missed the playoffs only once.

The 49ers boast a proud lineage of legendary players, including Joe Montana, Steve Young, Jerry Rice, Roger Craig, Ronnie Lott, and Dwight Clark, who have all contributed to the franchise's storied legacy. Since 2012, the 49ers have made three more Super Bowl appearances, though they fell short each time. Kyle Shanahan has led the franchise through two of its most recent Super Bowl losses. If the third attempt proves successful, should it occur, Brock Purdy, Christian McCaffrey, Deebo Samuel, Trent Williams, and Nick Bosa could join the ranks of the team's esteemed legends.

San Francisco 49ers Past Seasons(2000)

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